Transepithelial ion transport across duct cells of the salivary gland

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19 Scopus citations


Fluid and electrolyte secretions are vital for all epithelia and when aberrant lead to numerous pathophysiological conditions. Electrolyte transport across epithelia generates the osmotic force for fluid movement and is mediated by several membrane proteins expressed on both apical and basolateral poles of epithelial cells. Sodium and chloride are crucial for regulation of fluid secretion, thus regulating salivary volume. Bicarbonate (HCO-3), on the other hand, is the major pH buffer; hence, aberrant HCO-3 secretion is a major factor in diseases such as cystic fibrosis (CF) causing altered mucin hydration and solubilization. Here, the structure-function mechanisms of the major membrane transporters involved in salivary duct electrolyte transport are reviewed focusing on transepithelial movement of Cl- and HCO-3.

Original languageEnglish
Pages (from-to)826-835
Number of pages10
JournalOral Diseases
Issue number7
StatePublished - 1 Oct 2015
Externally publishedYes


  • Bicarbonate
  • Duct
  • Epithelia
  • Salivary gland
  • Secretion
  • Transporters


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