Transfer of insulin lispro across the human placenta

Gershon Holcberg, Marina Tsadkin-Tamir, Olga Sapir, Arnon Wiznizer, David Segal, Hana Polachek, Zvi Ben Zvi

Research output: Contribution to journalEditorial

29 Scopus citations

Abstract

Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.

Original languageEnglish
Pages (from-to)117-118
Number of pages2
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volume115
Issue number1
DOIs
StatePublished - 15 Jul 2004

Keywords

  • Human placenta
  • Insulin lispro
  • Perfusion

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