Transfer of insulin lispro across the human placenta

Gershon Holcberg, Marina Tsadkin-Tamir, Olga Sapir, Arnon Wiznizer, David Segal, Hana Polachek, Zvi Ben Zvi

    Research output: Contribution to journalEditorial

    32 Scopus citations

    Abstract

    Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.

    Original languageEnglish
    Pages (from-to)117-118
    Number of pages2
    JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
    Volume115
    Issue number1
    DOIs
    StatePublished - 15 Jul 2004

    Keywords

    • Human placenta
    • Insulin lispro
    • Perfusion

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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