Transfer of insulin lispro across the human placenta

Gershon Holcberg; Marina Tsadkin-Tamir; Olga Sapir; Arnon Wiznizer; David Segal; Hana Polachek; Zvi Ben Zvi

doi:10.1016/j.ejogrb.2003.10.006

Transfer of insulin lispro across the human placenta

Gershon Holcberg, Marina Tsadkin-Tamir, Olga Sapir, Arnon Wiznizer, David Segal, Hana Polachek, Zvi Ben Zvi

Research output: Contribution to journal › Editorial

32 Scopus citations

Abstract

Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.

Original language	English
Pages (from-to)	117-118
Number of pages	2
Journal	European Journal of Obstetrics, Gynecology and Reproductive Biology
Volume	115
Issue number	1
DOIs	https://doi.org/10.1016/j.ejogrb.2003.10.006
State	Published - 15 Jul 2004

Keywords

Human placenta
Insulin lispro
Perfusion

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejogrb.2003.10.006

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title = "Transfer of insulin lispro across the human placenta",

abstract = "Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.",

keywords = "Human placenta, Insulin lispro, Perfusion",

author = "Gershon Holcberg and Marina Tsadkin-Tamir and Olga Sapir and Arnon Wiznizer and David Segal and Hana Polachek and Zvi, {Zvi Ben}",

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T1 - Transfer of insulin lispro across the human placenta

AU - Holcberg, Gershon

AU - Tsadkin-Tamir, Marina

AU - Sapir, Olga

AU - Wiznizer, Arnon

AU - Segal, David

AU - Polachek, Hana

AU - Zvi, Zvi Ben

PY - 2004/7/15

Y1 - 2004/7/15

N2 - Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.

AB - Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.

KW - Human placenta

KW - Insulin lispro

KW - Perfusion

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U2 - 10.1016/j.ejogrb.2003.10.006

DO - 10.1016/j.ejogrb.2003.10.006

M3 - Editorial

AN - SCOPUS:3042691760

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SP - 117

EP - 118

JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

SN - 0028-2243

IS - 1

ER -

Transfer of insulin lispro across the human placenta

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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