Transient enhanced cell division by blocking DNA synthesis in Escherichia coli

Carmen Mata Martín, Arieh Zaritsky, Itzhak Fishov, Elena C. Guzmán

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Duplication of the bacterial nucleoid is necessary for cell division hence specific arrest of DNA replication inhibits divisions culminating in filamentation, nucleoid dispersion and appearance of a-nucleated cells. It is demonstrated here that during the first 10 min however, Escherichia coli enhanced residual divisions: the proportion of constricted cells doubled (to 40%), nucle-oids contracted and cells remodelled dimensions: length decreased and width increased. The preliminary data provides further support to the existence of temporal and spatial couplings between the nucleoid/replisome and the sacculus/divisome, and is consistent with the idea that bacillary bacteria modulate width during the division process exclusively.

Original languageEnglish
Article number000888
Pages (from-to)516-521
Number of pages6
JournalMicrobiology
Volume166
Issue number6
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Cell division and dimensions
  • DNA replication
  • Nucleoid morphology

ASJC Scopus subject areas

  • Microbiology

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