Transient normal platelet counts and decreased requirement for interferon during pregnancy in essential thrombocythaemia

Ofer Shpilberg, Ilan Shimon, Orit Sofer, Mordechai Dolitski, Isaac Ben-Bassat

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We report on the remarkable decrease in the platelet counts during pregnancy in two women with essential thrombocythaemia following treatment with recombinant interferon-α (r-IFN-α). Prior to pregnancy, the first patient was treated for 10 months with r-IFN-α 3 x 106 units/d six times per week, and the platelet count ranged between 750 and 800 x 109/l. Starting from the sixth week of gestation, the platelet count decreased to normal levels and remained so, resulting in a lower r-IFN-α requirement. Following successful delivery of a healthy newborn an abrupt rise of the platelet count to pre-gestation values was observed, necessitating increased r-IFN-α dosage as before pregnancy. The second patient when she became pregnant had been treated with r-IFN-α 3 x 106 units/d six times per week for 10 weeks. Starting from the 24th week of gestation the platelet count decreased, and despite reduction in the dose of r-IFN-α reached normal values at the time of delivery. The exact mechanism for the platelet count normalization during pregnancy is unclear, and several possibilities are discussed.

Original languageEnglish
Pages (from-to)491-493
Number of pages3
JournalBritish Journal of Haematology
Volume92
Issue number2
DOIs
StatePublished - 1 Jan 1996

Keywords

  • Essential thrombocythaemia
  • Pregnancy
  • Recombinant interferon-α

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