We report on the remarkable decrease in the platelet counts during pregnancy in two women with essential thrombocythaemia following treatment with recombinant interferon-α (r-IFN-α). Prior to pregnancy, the first patient was treated for 10 months with r-IFN-α 3 x 106 units/d six times per week, and the platelet count ranged between 750 and 800 x 109/l. Starting from the sixth week of gestation, the platelet count decreased to normal levels and remained so, resulting in a lower r-IFN-α requirement. Following successful delivery of a healthy newborn an abrupt rise of the platelet count to pre-gestation values was observed, necessitating increased r-IFN-α dosage as before pregnancy. The second patient when she became pregnant had been treated with r-IFN-α 3 x 106 units/d six times per week for 10 weeks. Starting from the 24th week of gestation the platelet count decreased, and despite reduction in the dose of r-IFN-α reached normal values at the time of delivery. The exact mechanism for the platelet count normalization during pregnancy is unclear, and several possibilities are discussed.
|Number of pages||3|
|Journal||British Journal of Haematology|
|State||Published - 1 Jan 1996|
- Essential thrombocythaemia
- Recombinant interferon-α