Translocation of effectors: Revisiting the injectosome model

Neta Sal-Man, Matthew A. Croxen, B. Brett Finlay

Research output: Contribution to journalArticlepeer-review


Type III secretion systems suppress host immune response and modify cell-signaling and regulation pathways by translocation of virulence proteins, called effectors, from the bacteria into the cytosol of the target cells. The common belief was that effectors translocate by a single step mechanism through a continuous channel built up by type III secretion systems. In this article, Akopyan et al. propose an alternative, and possibly parallel, two-step model to translocate effectors into target cells. According to their model, effectors first localized on the surface of the bacterial membrane, followed by a type III secretion system-dependent entry into the host cell.

Original languageEnglish
Pages (from-to)483-484
Number of pages2
JournalFuture Microbiology
Issue number5
StatePublished - 1 May 2011
Externally publishedYes


  • Yersinia
  • bacterial pathogenesis
  • effectors
  • type III secretion

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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