Translocation t(11;14) in newly diagnosed patients with multiple myeloma: Is it always favorable?

Merav Leiba, Adrian Duek, Ninette Amariglio, Abraham Avigdor, Noam Benyamini, Izhar Hardan, Itay Zilbershats, Chezi Ganzel, Olga Shevetz, Ilya Novikov, Yossi Cohen, Galina Ishoev, Gabriela Rozic, Arnon Nagler, Luba Trakhtenbrot

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The most common translocation in multiple myeloma (MM) is t(11;14)(q13;q32). According to several studies, this translocation represents a unique subset of patients with relatively favorable outcomes. Using combined analyses of morphology and fluorescence in situ hybridization (I-FISH), we examined the co-occurrence rates of t(11;14) with seven chromosomal aberrations (CAs), del(13q), del(17p), del(1p), gain(1q), multiple gains(1q), del(16q), and del(IGH), and assessed the effect of the different combinations on patient outcomes, with overall survival (OS) as the main outcome measure. Bone marrow samples and clinical data from 212 patients with MM with t(11;14) were analyzed. At least two additional CAs were found in 35% (75/205) of patients and a strong correlation between specific CAs. The occurrence of three CAs [multiple gains of (1q) (HR = 6.94, P = 0.001), del(1p) (HR = 4.47, P = 0.008), and del(IGH) (HR = 2.38, P = 0.002)] exerted a profoundly deleterious effect on median OS when compared with patients with t(11;14) only. Del(17p) and del(13q) have also exerted a deleterious effect albeit to a lesser extent (HR = 2.05, P = 0.07 and HR = 1.81, P = 0.03, respectively). When compared with t(11;14) alone, the addition of certain CAs lead to worse outcomes. These findings may have important clinical and biological implications. Patients with coexisting adverse lesions and t(11;14) may be considered at high risk and managed accordingly.

Original languageEnglish
Pages (from-to)710-718
Number of pages9
JournalGenes Chromosomes and Cancer
Issue number9
StatePublished - 1 Sep 2016
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research


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