Abstract
Prodrugs are bioreversible derivatives of drug molecules designed to overcome pharmaceutical, pharmacokinetic, or pharmacodynamic barriers such as low oral absorption, lack of site-specificity, insufficient chemical stability, poor solubility, toxicity, unacceptable taste/odor, etc. The prodrug approach becomes more and more popular and successful; to date, around 10% of all the world’s marketed medications are prodrugs, 20% of all small molecular medicines approved between 2000 and 2008 were prodrugs, and when focusing on 2008 approved drugs, it emerges that over 30% of them were prodrugs (Huttunen et al., 2011; Stella, 2010).
Original language | English |
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Title of host publication | Drug Delivery |
Subtitle of host publication | An Integrated Clinical and Engineering Approach |
Publisher | CRC Press |
Pages | 47-64 |
Number of pages | 18 |
ISBN (Electronic) | 9781466565951 |
ISBN (Print) | 9781466565944 |
DOIs | |
State | Published - 1 Jan 2017 |
ASJC Scopus subject areas
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics