Treatment of advanced gastric cancer with DDP (cisplatin), Adriamycin, and 5-fluorouracil (DAF)

R. Epelbaum, N. Haim, M. Stein, Y. Cohen, E. Robinson

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations


    Sixteen evaluable patients with advanced gastric cancer who had no prior therapy were treated intravenously with cisplatin (DDP) 20 mg/m2/day on days 1-5 and with Adriamycin 40 mg/m2 and 5-fluorouracil 600 mg/m2 on day 1 (DAF) every 3 weeks. There were five objective partial responses, giving a response rate of 31%. Five patients had minor responses, and 5 others achieved disease stabilization. The median duration of response for responders was 10 months, and the median time to tumor progression in nonresponders was 6 months. The overall median survival was 12 months (responders 14 months, nonresponders 9 months; NS). Most patients had a subjective improvement, including disappearance of abdominal pain (7/9) and gastrointestinal bleeding (5/7). The drug toxicity was moderate to severe. The primary nonhematologic toxicities were nausea and vomiting (in all patients), severe weakness (44%), and parasthesias (31%). Eight patients (50%) experienced significant bone marrow suppression. The DAF combination appears to have some activity in patients with advanced gastric cancer. However, further efforts in new drug development and other combinations are needed to improve the results of chemotherapy in stomach cancer.

    Original languageEnglish
    Pages (from-to)201-206
    Number of pages6
    Issue number4
    StatePublished - 1 Jan 1987

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research


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