Treatment of chronic bilateral pleural effusions with intravenous immunoglobulin and cyclosporin

Y. Sherer, P. Langevitz, Y. Levy, F. Fabrizzi, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A 48 y old woman with unremarkable medical history was admitted with bilateral pleural effusions; even though the fluid was drained, it re-accumulated and necessitated many repeated drainages in the following 2.5 y (56 hospitalisations). The patient underwent an extensive diagnostic work-up that disclosed elevated serum antinuclear antibodies, serum anti-dsDNA antibodies, pleural fluid anti-dsDNA and decreased pleural fluid C3 and C4. During that period she has been treated with a variety of immunomodulating agents, several pleural talcage and pleurectomy, without any apparent response. Thereafter, she received six courses of IVIg (2 g/kg body weight) in monthly intervals, followed by four months treatment with cyclosporin. This treatment resulted in gradual and eventually complete disappearance of the pleural effusion, and now after more than 2 y the patient is free of symptoms and receives no further medications.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
Issue number4
StatePublished - 5 Jul 1999
Externally publishedYes


  • Autoimmunity
  • Cyclosporin
  • Intravenous immunoglobulin
  • Pleural effusion
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology


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