Treatment of chronic intractable neuropathic pain with dronabinol: Case report of two adolescents

Zvia Rudich, Jennifer Stinson, Michael Jeavons, Stephen C. Brown

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


OBJECTIVE: To evaluate the effectiveness of dronabinol for the treatment of neuropathic pain refractory to previous treatment. METHODS: We studied the response (reduction of pain intensity and functional improvement) to dronabinol (5 mg/day to 25 mg/day) in two adolescents with neuropathic pain and depression refractory to previous treatments over two and five years, respectively. RESULTS: Reduction in pain intensity (45%) was achieved in patient 2 and was unchanged in patient 1. Functional improvement was markedly increased in terms of academic performance, mood and sleep in both patients over four to five months, without major adverse effects. While these improvements dissipated over time, the patients were more reconnected with rehabilitation and focused less on the intrusiveness of their pain problem in their every day lives. CONCLUSIONS: Dronabinol appeared to be effective in improving pain affect and psychosocial functioning in the treatment of refractory neuropathic pain and may be considered as an adjuvant medication in the rehabilitation process. Well-controlled placebo studies are required for further evaluation.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalPain Research and Management
Issue number4
StatePublished - 1 Jan 2003
Externally publishedYes


  • Adolescents
  • Dronabinol
  • Neuropathic pain

ASJC Scopus subject areas

  • Neurology
  • Anesthesiology and Pain Medicine


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