TY - JOUR
T1 - Treatment of Diabetic Perforating Ulcers (Mal Perforant) with Local Dimethylsulfoxide
AU - Ravid, Mordchai
AU - Lang, Ruth
AU - Kedar, Igal
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Perforating foot ulcers constitute a major problem in diabetics with peripheral neuropathy for which no specific therapy is available. Twenty patients with chronic, resistant mal perforant were treated by local application of dimethylsulfoxide (DMSO) solution. Complete healing of the ulcers was achieved in 14 patients following 4–15 weeks of daily treatment. Partial resolution was observed in another four patients, and in the remaining two there was no effect. A control group, equal in number, was treated conventionally. Complete healing of the ulcers took place in only two patients. The therapeutic effect of DMSO most probably results from an increase in tissue oxygen saturation via a combined mechanism of local vasodilatation, decreased thrombocyte aggregation, and increased oxygen diffusion. Local DMSO is effective, simple, devoid of systemic side effects, and inexpensive. It should be employed for diabetic foot ulcers prior to the consideration of surgical measures. J Am Geriatr Soc 33:41, 1985 1985 The American Geriatrics Society
AB - Perforating foot ulcers constitute a major problem in diabetics with peripheral neuropathy for which no specific therapy is available. Twenty patients with chronic, resistant mal perforant were treated by local application of dimethylsulfoxide (DMSO) solution. Complete healing of the ulcers was achieved in 14 patients following 4–15 weeks of daily treatment. Partial resolution was observed in another four patients, and in the remaining two there was no effect. A control group, equal in number, was treated conventionally. Complete healing of the ulcers took place in only two patients. The therapeutic effect of DMSO most probably results from an increase in tissue oxygen saturation via a combined mechanism of local vasodilatation, decreased thrombocyte aggregation, and increased oxygen diffusion. Local DMSO is effective, simple, devoid of systemic side effects, and inexpensive. It should be employed for diabetic foot ulcers prior to the consideration of surgical measures. J Am Geriatr Soc 33:41, 1985 1985 The American Geriatrics Society
UR - http://www.scopus.com/inward/record.url?scp=0021960292&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.1985.tb02858.x
DO - 10.1111/j.1532-5415.1985.tb02858.x
M3 - Article
C2 - 3880781
AN - SCOPUS:0021960292
SN - 0002-8614
VL - 33
SP - 41
EP - 43
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 1
ER -