Therapie der Tinea capitis-Griseofulvin versus Fluconazol-eine vergleichende Studie

Translated title of the contribution: Treatment of tinea capitis-griseofulvin versus fluconazole-a comparative study

Avner Shemer, Ira Bernstein Plotnik, Batya Davidovici, Marcelo H. Grunwald, Ronen Magun, Boaz Amichai

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective To compare the efficacy and safety of fluconazole and griseofulvin in the treatment of tinea capitis. Patients and Methods Patients with tinea capitis (n = 113) with positive fungal cultures entered the study. The patients were divided into four groups with different treatment regimes. Two groups received griseofulvin 15 or 25 mg/kg/day and two groups received fluconazole 4 or 6 mg/kg/day, all for up to 12 weeks. Results Griseofulvin was found to be slightly better than fluconazole. The lower doses for both griseofulvin and fluconazole required significantly longer treatment duration until mycological cure than the higher doses, independent of the fungus type. Conclusions Since no significant difference was found between the drugs, it is suggested that the choice should be based on tolerability, availability and cost of the drugs.

Translated title of the contributionTreatment of tinea capitis-griseofulvin versus fluconazole-a comparative study
Original languageGerman
Pages (from-to)737-741
Number of pages5
JournalJDDG - Journal of the German Society of Dermatology
Volume11
Issue number8
DOIs
StatePublished - 1 Jan 2013
Externally publishedYes

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