Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis

David Shoseyov, Haim Bibi, Pintov Shai, Nurit Shoseyov, Gila Shazberg, Haggit Hurvitz

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


Background: Chronic sinusitis (CS) is a common disease in children, especially those with allergies, that is caused by impaired drainage from the sinuses. Hypertonic NaCl solution has been shown to increase mucociliary clearance and ciliary beat frequency. Objective: We performed a randomized double blind study to compare the effect of nasal wash with hypertonic saline (HS) (3.5%) versus normal saline (NS) (0.9%) on CS. Methods: Thirty patients with CS aged 3 to 16 years were studied. They were randomly divided into two treatment groups matched by age and severity of the disease. Each individual was treated with either HS or NS for 4 weeks. All patients were evaluated by two clinical scores (cough and nasal secretions/postnasal drip [PND]) and by a radiology score at the beginning of the study and after 4 weeks. Results: The HS group improved significantly in all scores (average ± SD): cough score, from 3.6 ± 0.51 to 1.6 ± 0.74; nasal secretion/PND score, from 2.86 ± 0.35 to 1.6 ± 0.74; and radiology score, from 8.06 ± 1.28 to 2.66 ± 1.04. The NS treatment group showed significant improvement only in the PND score (from 2.66 ± 0.49 to 1.53 ± 0.83) but no significant change in both the cough score (from 3.53 ± 0.52 to 3.33 ± 0.49) and the radiology score (from 8.13 ± 1.25 to 7.86 ± 0.91). Clinical observation 1 month after the end of the study showed no change compared with the end of the study in both groups. Conclusion: HS nasal wash is an efficient treatment of CS.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Issue number5
StatePublished - 1 Jan 1998
Externally publishedYes


  • Chronic sinusitis
  • Hypertonic saline

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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