TY - JOUR
T1 - Tricarbonyltechnetium(i) and tricarbonylrhenium(i) complexes of amino acids
T2 - Crystal and molecular structure of a novel cyclic dimeric Re(CO) 3-amino acid complex comprised of the OON donor atom set of the tridentate ligand
AU - Nayak, Dipak Kumar
AU - Halder, Kamal Krishna
AU - Baishya, Rinku
AU - Sen, Tuhinadri
AU - Mitra, Partha
AU - Debnath, Mita Chatterjee
PY - 2013/10/7
Y1 - 2013/10/7
N2 - Radiolabeled complexes of monoamino polycarboxylic, polyamino monocarboxylic and thiol containing amino acid ligands were prepared from a fac-[99mTc(CO)3(H2O)3]+ precursor.The overall radiochemical yield was 94-98%. The complexes exhibited substantial in vitro and in vivo stability. The corresponding Re(i) complexes of the ligands DAPA, Asp and CysH were prepared and characterized by means of IR, NMR, and MS spectroscopic studies, as well as X-ray crystallography (for those containing d,l-DAPA and d,l-Asp). The rhenium complexes have been structurally correlated with the technetium complexes by means of HPLC studies. The reaction of Re(CO)5Cl with d,l-Asp in presence of triethylamine led to the formation of a new class of cyclic dimeric complexes formed by the OON donor atom set of the tridentate ligands. The amino carboxylate ligand system formed well defined complexes with a fac-[M(CO)3(H2O) 3]+ core and shows good promise in 99mTc(CO) 3 tracer development.
AB - Radiolabeled complexes of monoamino polycarboxylic, polyamino monocarboxylic and thiol containing amino acid ligands were prepared from a fac-[99mTc(CO)3(H2O)3]+ precursor.The overall radiochemical yield was 94-98%. The complexes exhibited substantial in vitro and in vivo stability. The corresponding Re(i) complexes of the ligands DAPA, Asp and CysH were prepared and characterized by means of IR, NMR, and MS spectroscopic studies, as well as X-ray crystallography (for those containing d,l-DAPA and d,l-Asp). The rhenium complexes have been structurally correlated with the technetium complexes by means of HPLC studies. The reaction of Re(CO)5Cl with d,l-Asp in presence of triethylamine led to the formation of a new class of cyclic dimeric complexes formed by the OON donor atom set of the tridentate ligands. The amino carboxylate ligand system formed well defined complexes with a fac-[M(CO)3(H2O) 3]+ core and shows good promise in 99mTc(CO) 3 tracer development.
UR - http://www.scopus.com/inward/record.url?scp=84883542523&partnerID=8YFLogxK
U2 - 10.1039/c3dt50928a
DO - 10.1039/c3dt50928a
M3 - Article
C2 - 23900487
AN - SCOPUS:84883542523
SN - 1477-9226
VL - 42
SP - 13565
EP - 13575
JO - Dalton Transactions
JF - Dalton Transactions
IS - 37
ER -