TY - JOUR
T1 - Trichothecenes in food and feed
T2 - Occurrence, impact on human health and their detection and management strategies
AU - Mahato, Dipendra Kumar
AU - Pandhi, Shikha
AU - Kamle, Madhu
AU - Gupta, Akansha
AU - Sharma, Bharti
AU - Panda, Brajesh Kumar
AU - Srivastava, Shubhangi
AU - Kumar, Manoj
AU - Selvakumar, Raman
AU - Pandey, Arun Kumar
AU - Suthar, Priyanka
AU - Arora, Shalini
AU - Kumar, Arvind
AU - Gamlath, Shirani
AU - Bharti, Ajay
AU - Kumar, Pradeep
N1 - Publisher Copyright:
© 2022
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Trichothecenes (TCNs) are the mycotoxins produced by many fungal species such as Fusarium, Myrothecium, and Stachybotrys and pose a considerable health risk. Based on their characteristic functional moieties, they are divided into four categories: Type A (T-2, HT-2, diacetoxyscirpenol (DAS), harzianum A, neosolaniol (NEO) and trichodermin), Type B (deoxynivalenol (DON), nivalenol (NIV), trichothecin and fusarenon X), Type C (crotocin) and Type D (satratoxin G & H, roridin A and verrucarin A) with types A and B being the most substantial. TCNs cause growth retardation in eukaryotes, suppress seedling growth or regeneration in plants and could be a reason for animal reproductive failure. Due to the increased frequency of occurrence and widespread distribution of TCNs in food and feed, knowledge of their sources of occurrence is essential to strategise their control and management. Hence, this review provides an overview of various types and sources of TCNs, the associated biosynthetic pathways and genes responsible for production in food and feed. Further, various processing and environmental effects on TCNs production, detection techniques and management strategies are also briefly outlined.
AB - Trichothecenes (TCNs) are the mycotoxins produced by many fungal species such as Fusarium, Myrothecium, and Stachybotrys and pose a considerable health risk. Based on their characteristic functional moieties, they are divided into four categories: Type A (T-2, HT-2, diacetoxyscirpenol (DAS), harzianum A, neosolaniol (NEO) and trichodermin), Type B (deoxynivalenol (DON), nivalenol (NIV), trichothecin and fusarenon X), Type C (crotocin) and Type D (satratoxin G & H, roridin A and verrucarin A) with types A and B being the most substantial. TCNs cause growth retardation in eukaryotes, suppress seedling growth or regeneration in plants and could be a reason for animal reproductive failure. Due to the increased frequency of occurrence and widespread distribution of TCNs in food and feed, knowledge of their sources of occurrence is essential to strategise their control and management. Hence, this review provides an overview of various types and sources of TCNs, the associated biosynthetic pathways and genes responsible for production in food and feed. Further, various processing and environmental effects on TCNs production, detection techniques and management strategies are also briefly outlined.
KW - Detection and management strategies
KW - Food and feed contamination
KW - Human health
KW - Trichothecenes
UR - http://www.scopus.com/inward/record.url?scp=85123780532&partnerID=8YFLogxK
U2 - 10.1016/j.toxicon.2022.01.011
DO - 10.1016/j.toxicon.2022.01.011
M3 - Review article
C2 - 35104534
AN - SCOPUS:85123780532
SN - 0041-0101
VL - 208
SP - 62
EP - 77
JO - Toxicon
JF - Toxicon
ER -