Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21

Ada H. Zohar, Christian Dina, Naama Rosolio, Yamima Osher, Inga Gritsenko, Rachel Bachner-Melman, Jonathan Benjamin, Robert H. Belmaker, Richard P. Ebstein

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Human personality traits are moderately heritable but only recently have specific polymorphisms been associated with particular personality dimensions especially anxiety-related and novelty-seeking traits. The first genome-wide scan for personality traits was recently carried out by Cloninger et al. [1998: Am J Med Genet 81:313-317] and his colleagues and they reported that a region on 8p21 showed linkage to TPQ Harm Avoidance, an anxiety-related personality trait. Towards replicating and extending these results, we examined both 8p21 and two additional chromosomal regions (1q21-24 and 22q12-13) for linkage to TPQ personality traits by genotyping at least three microsatellite markers in each region in a group of 384 sibling pairs. We found evidence for linkage to TPQ HA at 8p21-23 (Lod score = 2.907) confirming in an independent sample the initial findings by Cloninger and his colleagues.

Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume117 B
Issue number1
StatePublished - 15 Feb 2003


  • Anxiety-related trait
  • Chromosome 8
  • Harm avoidance
  • Linkage
  • Personality
  • QTL
  • Quantitative trait locus
  • Schizophrenia
  • TPQ
  • Tridimensional personality questionnaire

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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