Trigger chemistries for better industrial formulations

Hsuan Chin Wang, Yanfeng Zhang, Catherine M. Possanza, Steven C. Zimmerman, Jianjun Cheng, Jeffrey S. Moore, Keith Harris, Joshua S. Katz

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


In recent years, innovations and consumer demands have led to increasingly complex liquid formulations. These growing complexities have provided industrial players and their customers access to new markets through product differentiation, improved performance, and compatibility/stability with other products. One strategy for enabling more complex formulations is the use of active encapsulation. When encapsulation is employed, strategies are required to effect the release of the active at the desired location and time of action. One particular route that has received significant academic research effort is the employment of triggers to induce active release upon a specific stimulus, though little has translated for industrial use to date. To address emerging industrial formulation needs, in this review, we discuss areas of trigger release chemistries and their applications specifically as relevant to industrial use. We focus the discussion on the use of heat, light, shear, and pH triggers as applied in several model polymeric systems for inducing active release. The goal is that through this review trends will emerge for how technologies can be better developed to maximize their value through industrial adaptation.

Original languageEnglish
Pages (from-to)6369-6382
Number of pages14
JournalACS applied materials & interfaces
Issue number12
StatePublished - 1 Apr 2015
Externally publishedYes


  • UV-induced
  • capsule
  • depolymerization
  • polymersome
  • self-assembly
  • triggered release

ASJC Scopus subject areas

  • General Materials Science


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