Triggering final follicular maturation- hCG, GnRH-agonist or both, when and to whom?

Raoul Orvieto

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Controlled ovarian hyperstimulation (COH) which combines GnRH antagonist co-treatment and GnRH-agonist (GnRHa) trigger has become a common tool aiming to eliminate severe early OHSS and to support the concept of an OHSS-free clinic. However, due to the reported significantly reduced clinical, efforts have been made to improve reproductive outcome. One of the suggested optional strategies aiming to improve outcome was the addition of low-dose (1500 IU) HCG bolus, administered, concomitant, 35 h or 5 days after the triggering bolus of GnRHa. All these regimens were demonstrated to rescue the luteal phase, resulting in improved reproductive outcome in patients at risk to develop severe OHSS, compared to GnRHa trigger alone, however, with the questionable ability to eliminate severe OHSS. Moreover, following the observations demonstrating comparable or even better oocyte\embryos quality following GnRHa, compared to hCG trigger, and the different effects of LH and hCG on the downstream signaling of the LH receptor, GnRHa is now offered concomitant to the standard hCG trigger dose to improve oocyte/embryo yield and quality. GnRHa and hCG may be offered either concomitantly, 35-37 h prior to oocyte retrieval (dual trigger), or 40 h and 34 h prior to oocyte retrieval, respectively (double trigger).

Original languageEnglish
Article number60
JournalJournal of Ovarian Research
Issue number1
StatePublished - 21 Aug 2015
Externally publishedYes


  • Controlled ovarian hyperstimulation
  • GnRH agonist
  • OHSS
  • Oocyte quality
  • Ovulation
  • Trigger
  • hCG

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


Dive into the research topics of 'Triggering final follicular maturation- hCG, GnRH-agonist or both, when and to whom?'. Together they form a unique fingerprint.

Cite this