Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina

Esther Manor, Lipa Bodner, Palina Kachko, Josef Kapelushnik

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Sarcoma botryoides (SB) is a subtype of embryonal rhabdomyosarcoma (ERMS), which belongs to the most common soft-tissue sarcoma in infancy and childhood, the rhabdomyosarcoma (RMS). Most of the vaginal RMS belong to SB, which is five times more common than the cervical ERMS. To date, there is no doubt regarding the significance and importance of chromosomal aberrations in cancer. So far, to our knowledge, no specific chromosomal changes have been reported for ERMS in general and for SB in particular. We describe cytogenetic results of a case of vaginal SB affecting a 1-year-old girl. A clone of trisomy 8 was found in all the analyzed cells as the only chromosomal aberration. The significance of this finding is discussed.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume195
Issue number2
DOIs
StatePublished - 1 Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina'. Together they form a unique fingerprint.

Cite this