Tritium labelling of benzamide drugs

Ilan Pri‐Bar; Ouri Buchman

doi:10.1002/jlcr.2580201004

Tritium labelling of benzamide drugs

Ilan Pri‐Bar, Ouri Buchman

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. ³H‐sulpiride (7.1 Ci/mmol), ³H‐sultopride (2.1 Ci/mmol) and ³H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

Original language	English
Pages (from-to)	1153-1158
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	20
Issue number	10
DOIs	https://doi.org/10.1002/jlcr.2580201004
State	Published - 1 Jan 1983
Externally published	Yes

Keywords

metoclopramide
sulpiride
sultopride
tritiated benzamides

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.2580201004

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title = "Tritium labelling of benzamide drugs",

abstract = "Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.",

keywords = "metoclopramide, sulpiride, sultopride, tritiated benzamides",

author = "Ilan Pri‐Bar and Ouri Buchman",

year = "1983",

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T1 - Tritium labelling of benzamide drugs

AU - Pri‐Bar, Ilan

AU - Buchman, Ouri

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

AB - Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

KW - metoclopramide

KW - sulpiride

KW - sultopride

KW - tritiated benzamides

UR - http://www.scopus.com/inward/record.url?scp=0021089838&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580201004

DO - 10.1002/jlcr.2580201004

M3 - Article

AN - SCOPUS:0021089838

SN - 0362-4803

VL - 20

SP - 1153

EP - 1158

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 10

ER -

Tritium labelling of benzamide drugs

Abstract

Keywords

ASJC Scopus subject areas

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