Tritium labelling of benzamide drugs

Ilan Pri‐Bar, Ouri Buchman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

Original languageEnglish
Pages (from-to)1153-1158
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume20
Issue number10
DOIs
StatePublished - 1 Jan 1983
Externally publishedYes

Keywords

  • metoclopramide
  • sulpiride
  • sultopride
  • tritiated benzamides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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