Tryptophan reversal of recombinant human gamma-interferon inhibition of Chlamydia trachomatis growth

Yonat Shemer, Rina Kol, Israel Sarov

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Recombinant human gamma-interferon was shown to inhibit the growth of Chlamydia trachomatis (L2/434/Bu) in HEp-2 cells. This inhibition could be reversed by the addition of tryptophan. The effect of tryptophan was dose dependent and determined by the interferon concentration. At low concentrations of interferon, the addition of tryptophan completely restored C. trachomatis infectivity, whereas at high concentrations (100-1000 IU/ml) the effect of interferon could not be totally reversed. The reversal effect of tryptophan could be achieved even when the addition was 48 h after infection. The probability that tryptophan degradation induced by gamma-interferon might be the mechanism involved in its antichlamydial activity is discussed.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalCurrent Microbiology
Volume16
Issue number1
DOIs
StatePublished - 1 Jan 1987

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