Tubular handling of sodium following immersion to the neck and salt-induced volume expansion

J. Rapoport, C. Chaimovitz, A. Lisac, O. S. Better

Research output: Contribution to journalArticlepeer-review

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Abstract

We wished to compare the natriuretic and diuretic effect of extracellular volume expansion (ECVE) with 0.9% NaCl to that obtained with up-to-the-neck immersion (NI) in healthy volunteers. Clearance techniques during maximal antidiuretic hormone suppression were utilized to pinpoint the sites of tubular NaCl reabsorption. Mean glomerular filtration rate (GFR) did not differ significantly between ECVE and NI; mean rate of sodium excretion during ECVE was significantly greater than during NI, whereas mean water clearance for a given rate of distal delivery was higher with NI than with ECVE. Our findings suggest that ECVE is associated with greater natriuresis than NI, despite the equality of filtered sodium loads and of distal deliveries under both these procedures.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume18
Issue number6
StatePublished - 1 Jan 1982
Externally publishedYes

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