Tuftsin (an Ig-associated tetrapeptide) triggers the immunogenic function of macrophages: implications for activation of programmed cells

E. Tzehoval, S. Segal, Y. Stabinsky, M. Fridkin, Z. Spirer, M. Feldman

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

The immunoglobulin heavy-chain-associated tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), known for its phagocytosis-stimulating activity, was found to augment the antigen-specific, macrophage-dependent education of T lymphocytes. The investigation of stereospecific characteristics of the tetrapeptide, by use of structural analogs with different modifications, revealed strict structural requirements for eliciting the immunogenic activity of macrophages. It was found that the most important moiety for its activity is the dipeptide Pro-Arg. This finding is of interest in view of the appearance of this particular dipeptide in other bioregulatory peptides, including many of the peptide hormones. The significance of the appearance of a common structure in such molecules, which may act through specific receptors on different target cells, is discussed.

Original languageEnglish
Pages (from-to)3400-3404
Number of pages5
JournalPNAS Nexus
Volume75
Issue number7
DOIs
StatePublished - 1 Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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