Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Yaron Carmi; Tyler Prestwood; Edgar G. Engleman

doi:10.1080/2162402X.2015.1078063

Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Yaron Carmi, Tyler Prestwood, Edgar G. Engleman

Research output: Contribution to journal › Article › peer-review

Abstract

The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.

Original language	English
Article number	e1078063
Journal	OncoImmunology
Volume	8
Issue number	10
DOIs	https://doi.org/10.1080/2162402X.2015.1078063
State	Published - 1 Jan 2019
Externally published	Yes

Keywords

Dendritic cells
Fc receptors
Tumor-binding antibodies

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/2162402X.2015.1078063

Cite this

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title = "Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity",

abstract = "The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.",

keywords = "Dendritic cells, Fc receptors, Tumor-binding antibodies",

author = "Yaron Carmi and Tyler Prestwood and Engleman, {Edgar G.}",

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year = "2019",

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doi = "10.1080/2162402X.2015.1078063",

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AU - Carmi, Yaron

AU - Prestwood, Tyler

AU - Engleman, Edgar G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.

AB - The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.

KW - Dendritic cells

KW - Fc receptors

KW - Tumor-binding antibodies

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U2 - 10.1080/2162402X.2015.1078063

DO - 10.1080/2162402X.2015.1078063

M3 - Article

C2 - 31646066

AN - SCOPUS:85046677834

SN - 2162-4011

VL - 8

JO - OncoImmunology

JF - OncoImmunology

IS - 10

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ER -

Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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