Abstract
A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter-response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF-tumor hazard.
| Original language | English |
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| Patent number | US2021030799 |
| IPC | C12N 15/ 86 A I |
| Priority date | 14/02/19 |
| State | Published - 4 Feb 2021 |