Tumor immunoediting by NKp46

Moran Elboim, Roi Gazit, Chamutal Gur, Hormas Ghadially, Gili Betser-Cohen, Ofer Mandelboim

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

NK cells interact with a wide variety of hazardous cells including pathogen-infected and tumor cells. NKp46 is a specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands. It was recently shown that NKp46 plays a significant role in the in vivo eradication of tumor cells; however, the role played by NKp46 in vivo with regard to tumor development is still unclear. In this study, we used the 3-methylcholanthrene (MCA)-induced fibrosarcoma model in NKp46-deficient mice to test the NKp46 recognition of carcinogen-induced tumors.We show that although the rate of MCA-induced tumor formation was similar in the presence and in the absence of NKp46, the expression of its unknown ligands was NKp46 dependent. The unknown NKp46 ligands were nearly absent in tumors that originated in wild-type mice, whereas they were detected in tumors that originated in the NKp46-deficient mice.We demonstrate that the interactions between NKp46 and its MCA tumor-derived ligands lead to the secretion of IFN-γ but not to the elimination of the MCA-derived tumor cells. In addition, we show that the in vivo growth of MCA-derived tumor cells expressing high levels of the NKp46 ligands is NKp46 and IFN-γ dependent. Thus, we present in this study a novel NKp46-mediated mechanism of tumor editing.

Original languageEnglish
Pages (from-to)5637-5644
Number of pages8
JournalJournal of Immunology
Volume184
Issue number10
DOIs
StatePublished - 15 May 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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