Tumor-infiltrating immune cells promoting tumor invasion and metastasis: Existing theories

Yan Gao Man, Alexander Stojadinovic, Jeffrey Mason, Itzhak Avital, Anton Bilchik, Bjoern Bruecher, Mladjan Protic, Aviram Nissan, Mina Izadjoo, Xichen Zhang, Anahid Jewett

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations

Abstract

It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between tumor cells and infiltrated immune cells is associated with physical destructions of the tumor cells, reduction of the tumor burden, and improved clinical prognosis. An increasing number of studies, however, have suggested that aberrant infiltration of immune cells into tumor or normal tissues may promote tumor progression, invasion, and metastasis. Neither the primary reason for these contradictory observations, nor the mechanism for the reported diverse impact of tumor-infiltrating immune cells has been elucidated, making it difficult to judge the clinical implications of infiltration of immune cells within tumor tissues. This mini-review presents several existing hypotheses and models that favor the promoting impact of tumor-infiltrating immune cells on tumor invasion and metastasis, and also analyzes their strength and weakness.

Original languageEnglish
Pages (from-to)84-95
Number of pages12
JournalJournal of Cancer
Volume4
Issue number1
DOIs
StatePublished - 30 Aug 2013
Externally publishedYes

Keywords

  • Immune cell
  • Invasion
  • Metastasis
  • Tumor progression

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