Tumour scanning with indium-111 dihaematoporphyrin ether

M. R. Quastel, A. M. Richter, J. G. Levy

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Photofrin II (dihaematoporphyrin ether/ester, DHE) was labelled with indium-i 11 and its biodistribution in tumour bearing mice compared with that of 111In chloride. The uptake and clearance of 111In labelled DHE differed markedly from that of indium-l 1 chloride in that the former was not taken up by the tissues as much as the latter. Scintillation scanning with a gamma-camera showed marked uptake of both 111In agents at the site of the tumour, but a much lower tissue background (excluding the abdominal organs) for the mice given 111In DHE. Tumour:muscle ratios of dissected tissues were 2-3 times higher in 111In DHE treated animals as compared to the uptake of 111In chloride. There was a distinct difference in the pattern of distribution of the two 111In preparations in the tissues. The major accumulation of 111In chloride was in the kidneys, whereas the highest uptake of 111In DHE was in the liver, the organ in which unlabelled porphyrins accumulate. Extraction and testing of materials from tumours of 111In DHE treated animals indicated that most of the tumour extractable 111In had remained associated with the porphyrin in vivo up to 4 days after injection.

Original languageEnglish
Pages (from-to)885-890
Number of pages6
JournalBritish Journal of Cancer
Volume62
Issue number6
DOIs
StatePublished - 1 Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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