Twin pregnancy: Is it a risk factor for long-term cardiovascular disease?

Rania Okby, Ilana Shoham-Vardi, Ruslan Sergienko, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: To investigate whether twin pregnancy increases the risk for long-term maternal cardiovascular disease (CVD).Study design: A retrospective population-based cohort study compared the incidence of long-term CVD in a cohort of women with and without a previous twin delivery.Setting: Deliveries occurred between the years 1988 and 2012.Patients: Patients who had a twin birth between years 1988 and 2012 were included in the study, patient that had a singleton delivery included in the control group.Main outcome measures: CVD was divided into four categories according to severity and type. Kaplan-Meier survival curve was used to estimate cumulative incidence of cardiovascular hospitalizations. Cox proportional hazards model was used to estimate the adjusted hazard ratios (HR) for CVD.Results: During the study period, there were 100 387 women that met the inclusion criteria, 4.6% (n = 4647) delivered twins at least once during the period. The incidence of CVD was 1% in women who had a twin delivery and 1.12% in women who had a singleton delivery. There was no difference in the cumulative incidence of cardiovascular hospitalizations among women who had twin deliveries as compared with singletons. When performing a Cox proportional hazard model, a history of twin delivery did not increase the risk for long-term maternal cardiovascular hospitalizations (adjusted HR = 1.0, 95% CI = 0.8-1.1, p = 0.698).Conclusions: Twin pregnancy is not associated with an increased risk for long-term maternal CVD.

Original languageEnglish
Pages (from-to)1626-1630
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number10
StatePublished - 18 May 2016


  • Fertility treatment
  • long term cardiovascular disease
  • twin pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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