Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus

Benjamin Piura, Alex Rabinovich, Relly Hershkovitz, Ester Maor, Moshe Mazor

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations


    Introduction: Twin pregnancy with complete hydatidiform mole and co-existent fetus (CHMF) resulting in a healthy take-home baby is rare, with only 30 cases documented in detail in the literature. Case report: A 29-year-old woman conceived following two cycles of ovulation induction with clomiphene citrate. Successive ultrasound examinations demonstrated a normally growing live fetus alongside a normal placenta and an additional intrauterine echogenic mass with features of hydatidiform mole. At 17 week gestation, serum β-hCG level was 25.38 multiples of the median. Genetic amniocentesis at 18.5 week gestation showed normal fetal 46XX karyotype. A cesarean section performed at 28 week gestation resulted in the delivery of a live normal female infant and two adjoining placentas. One placenta was normal and the other placenta was composed of vesicles of various sizes. Microscopic examination of the abnormal placenta confirmed complete hydatidifrom mole. The baby did well and serial maternal serum β-hCG levels showed a declining trend and were undetectable by 7 weeks after delivery. Conclusion: Continuation of a twin pregnancy with CHMF is an acceptable option. There is, however, an increased risk of developing pre-eclampsia and fetal loss due to miscarriage. The chance of a live term birth is <50% with nearly 33% of the mothers developing persistent gestational trophoblastic disease after delivery. Thus, close surveillance of an ongoing twin pregnancy with CHMF is mandatory to detect potential early signs of maternal and fetal complications.

    Original languageEnglish
    Pages (from-to)377-382
    Number of pages6
    JournalArchives of Gynecology and Obstetrics
    Issue number4
    StatePublished - 1 Oct 2008


    • Hydatidiform mole
    • Karyotype
    • Placenta
    • Twin pregnancy
    • β-hCG

    ASJC Scopus subject areas

    • Obstetrics and Gynecology


    Dive into the research topics of 'Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus'. Together they form a unique fingerprint.

    Cite this