Two decades of pediatric celiac disease in a tertiary referral center: What has changed?

Alexander Krauthammer, Anat Guz-Mark, Noam Zevit, Luba Marderfeld, Orith Waisbourd-Zinman, Ari Silbermintz, Yael Mozer-Glassberg, Vered Nachmias Friedler, Michal Rozenfeld Bar Lev, Manar Matar, Amit Assa, Raanan Shamir

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Celiac disease (CD) is common worldwide with increasing prevalence and changing presentation. Aims: To evaluate changes in the presentation and management of CD over the last two decades. Methods: Retrospective chart review of pediatric patients with CD between 01.1999 to 12.2018 was performed. Comparisons were made between an early (1999 to 2008) and late (2009 to 2018) decade, regarding clinical and laboratory parameters at presentation and follow-up. Results: In a cohort of 932 patients (early decade n = 316, late decade n = 616), patients from the late decade presented with lower rates of weight loss and abdominal distention (24.2% vs 34.7% and 6% vs 11%, respectively p < 0.01), and with higher rates of abdominal pain or asymptomatic presentation (41.4% vs 27.4%, p < 0.01, and 18% vs 13%, p < 0.05, respectively). Good adherence to gluten-free diet was reported more often in the late decade (64% vs 50.6%, p < 0.001), and fewer patients were lost to follow-up. During the late decade, significantly higher rates of celiac serology normalization were achieved during the first two years of follow-up. Conclusion: In recent years, children with CD were diagnosed with milder symptoms, showed better adherence and demonstrated earlier normalization of celiac serology.

Original languageEnglish
Pages (from-to)457-461
Number of pages5
JournalDigestive and Liver Disease
Issue number4
StatePublished - 1 Apr 2020
Externally publishedYes


  • Children
  • Epidemiology
  • Follow up
  • Gluten free diet
  • Symptoms

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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