Two-dimensional order in β-sheet peptide monolayers

H. Rapaport, K. Kjaer, T. R. Jensen, L. Leiserowitz, D. A. Tirrell

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


Amphiphilic peptides comprising alternating hydrophilic and hydrophobic amino acid residues were designed to form super-secondary structures composed of self-assembled β-strands as monolayers at the air-water interface. Insights provided by in situ grazing-incidence X-ray diffraction (GIXD), surface pressure vs area isotherms, and Fourier transform infrared spectroscopy allow structural characterization of the assembled nanostructures and rational correlation with the peptide sequence. Peptides seven to seventeen amino acids in length were found to form crystalline arrays with coherence lengths in the range of 100 to 1000 Å. Two-dimensional registry of the self-assembled peptides was induced by placement of proline residues at the peptide termini. The films were found to intercalate ordered arrays of ions between juxtaposed β-sheet ribbons to generate peptide-ion composite phases.

Original languageEnglish
Pages (from-to)12523-12529
Number of pages7
JournalJournal of the American Chemical Society
Issue number50
StatePublished - 20 Dec 2000
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)
  • Biochemistry
  • Colloid and Surface Chemistry


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