Two successful pregnancies after in vitro fertilization and embryo transfer in a patient with endometrial atypical hyperplasia bordering on adenocarcinoma treated conservatively with high-dose progesterone

Benjamin Piura

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.

Original languageEnglish
Pages (from-to)21-23
Number of pages3
JournalGynecologic and Obstetric Investigation
Volume61
Issue number1
DOIs
StatePublished - 1 Jan 2006

Keywords

  • Assisted reproductive technologies
  • Endometrial carcinoma
  • Endometrial hyperplasia
  • Infertility
  • Pregnancy
  • Progesterone

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