Abstract
Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.
Original language | English |
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Pages (from-to) | 21-23 |
Number of pages | 3 |
Journal | Gynecologic and Obstetric Investigation |
Volume | 61 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2006 |
Keywords
- Assisted reproductive technologies
- Endometrial carcinoma
- Endometrial hyperplasia
- Infertility
- Pregnancy
- Progesterone
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology