Two successful pregnancies after in vitro fertilization and embryo transfer in a patient with endometrial atypical hyperplasia bordering on adenocarcinoma treated conservatively with high-dose progesterone

Benjamin Piura

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.

    Original languageEnglish
    Pages (from-to)21-23
    Number of pages3
    JournalGynecologic and Obstetric Investigation
    Volume61
    Issue number1
    DOIs
    StatePublished - 1 Jan 2006

    Keywords

    • Assisted reproductive technologies
    • Endometrial carcinoma
    • Endometrial hyperplasia
    • Infertility
    • Pregnancy
    • Progesterone

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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