TY - JOUR
T1 - Tyrosine phosphorylation of picot and its translocation to the nucleus in response of human t cells to oxidative stress
AU - Babichev, Yael
AU - Isakov, Noah
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Protein kinase C θ (PKCθ) is a Ca2+-independent isoform expressed in T but not B lymphocytes, and is therefore suggested as being linked to the T cell antigen receptor (TCR) function. PKCθ was shown to function as an upstream regulator of critical transcription factors, such as AP-1 and NF-KB, in activated T lymphocytes. More recent studies demonstrated that PKCθ colocalizes with the TCR at the core of the supramolecular activation complex (SMAC) formed at the contact region between antigen-responding T cells and antigen-presenting cells (APC). Finally, PKCθ—deficient mice were found to be impaired in T cell-mediated immune responses, apparently, due to inability of their antigen triggered T cells to activate the AP-1 and NF-κB transcription factors.
AB - Protein kinase C θ (PKCθ) is a Ca2+-independent isoform expressed in T but not B lymphocytes, and is therefore suggested as being linked to the T cell antigen receptor (TCR) function. PKCθ was shown to function as an upstream regulator of critical transcription factors, such as AP-1 and NF-KB, in activated T lymphocytes. More recent studies demonstrated that PKCθ colocalizes with the TCR at the core of the supramolecular activation complex (SMAC) formed at the contact region between antigen-responding T cells and antigen-presenting cells (APC). Finally, PKCθ—deficient mice were found to be impaired in T cell-mediated immune responses, apparently, due to inability of their antigen triggered T cells to activate the AP-1 and NF-κB transcription factors.
UR - http://www.scopus.com/inward/record.url?scp=0035701961&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-0685-0_6
DO - 10.1007/978-1-4615-0685-0_6
M3 - Article
AN - SCOPUS:0035701961
SN - 0065-2598
VL - 495
SP - 41
EP - 45
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -