Tyrosine phosphorylation of picot and its translocation to the nucleus in response of human t cells to oxidative stress

Yael Babichev, Noah Isakov

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Protein kinase C θ (PKCθ) is a Ca2+-independent isoform expressed in T but not B lymphocytes, and is therefore suggested as being linked to the T cell antigen receptor (TCR) function. PKCθ was shown to function as an upstream regulator of critical transcription factors, such as AP-1 and NF-KB, in activated T lymphocytes. More recent studies demonstrated that PKCθ colocalizes with the TCR at the core of the supramolecular activation complex (SMAC) formed at the contact region between antigen-responding T cells and antigen-presenting cells (APC). Finally, PKCθ—deficient mice were found to be impaired in T cell-mediated immune responses, apparently, due to inability of their antigen triggered T cells to activate the AP-1 and NF-κB transcription factors.
Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalAdvances in Experimental Medicine and Biology
Volume495
DOIs
StatePublished - 1 Jan 2001

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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