Tyrphostins reduce chemotherapy-induced intestinal injury in mice: Assessment by a biochemical assay

Y. Zlotnik, M. Patya, A. Vanichkin, A. Novogrodsky

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy, The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalBritish Journal of Cancer
Volume92
Issue number2
DOIs
StatePublished - 31 Jan 2005
Externally publishedYes

Keywords

  • Chemoprotection
  • Chemotherapy
  • Gamma-glutamyl transpeptidase
  • Intestinal injury
  • Tyrphostins

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