TY - JOUR
T1 - Ulcerative colitis
T2 - Patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort
AU - Höie, Ole
AU - Wolters, Frank
AU - Riis, Lene
AU - Aamodt, Geir
AU - Solberg, Camilla
AU - Bernklev, Tomm
AU - Odes, Selwyn
AU - Mouzas, Iannis A.
AU - Beltrami, Marina
AU - Langholz, Ebbe
AU - Stockbrügger, Reinhold
AU - Vatn, Morten
AU - Moum, Bjorn
PY - 2007/8/1
Y1 - 2007/8/1
N2 - OBJECTIVES: Cumulative 10-yr relapse rates in ulcerative colitis (UC) of 70% to almost 100% have been reported in regional studies. The aim of this study was to determine the relapse rate in UC in a European population-based cohort 10 yr after diagnosis and to identify factors that may influence the risk of relapse. METHODS: From 1991 to 1993, 771 patients with UC from seven European countries and Israel were prospectively included in a population-based inception cohort and followed for 10 yr. A relapse was defined as an increase in UC-related symptoms leading to changes in medical treatment or surgery. The cumulative relapse rate, time to first relapse, and number of relapses in the follow-up period were recorded and possible causative factors were investigated. RESULTS: The cumulative relapse rate of patients with at least one relapse was 0.67 (95% CI 0.63-0.71). The time to first relapse showed a greater hazard ratio (HR) (1.2, CI 1.0-1.5) for women and for patients with a high level of education (1.4, CI 1.1-1.8). The number of relapses decreased with age, and current smokers had a lower relapse rate (0.8, CI 0.6-0.9) than nonsmokers. The relapse rate in women was 1.2 (CI 1.1-1.3) times higher than in men. An inverse relation was found between the time to the first relapse and the total number of relapses. CONCLUSION: In 67% of patients, there was at least one relapse. Smoking status, level of education, and possibly female gender were found to influence the risk of relapse.
AB - OBJECTIVES: Cumulative 10-yr relapse rates in ulcerative colitis (UC) of 70% to almost 100% have been reported in regional studies. The aim of this study was to determine the relapse rate in UC in a European population-based cohort 10 yr after diagnosis and to identify factors that may influence the risk of relapse. METHODS: From 1991 to 1993, 771 patients with UC from seven European countries and Israel were prospectively included in a population-based inception cohort and followed for 10 yr. A relapse was defined as an increase in UC-related symptoms leading to changes in medical treatment or surgery. The cumulative relapse rate, time to first relapse, and number of relapses in the follow-up period were recorded and possible causative factors were investigated. RESULTS: The cumulative relapse rate of patients with at least one relapse was 0.67 (95% CI 0.63-0.71). The time to first relapse showed a greater hazard ratio (HR) (1.2, CI 1.0-1.5) for women and for patients with a high level of education (1.4, CI 1.1-1.8). The number of relapses decreased with age, and current smokers had a lower relapse rate (0.8, CI 0.6-0.9) than nonsmokers. The relapse rate in women was 1.2 (CI 1.1-1.3) times higher than in men. An inverse relation was found between the time to the first relapse and the total number of relapses. CONCLUSION: In 67% of patients, there was at least one relapse. Smoking status, level of education, and possibly female gender were found to influence the risk of relapse.
UR - http://www.scopus.com/inward/record.url?scp=34547646333&partnerID=8YFLogxK
U2 - 10.1111/j.1572-0241.2007.01265.x
DO - 10.1111/j.1572-0241.2007.01265.x
M3 - Article
C2 - 17555460
AN - SCOPUS:34547646333
SN - 0002-9270
VL - 102
SP - 1692
EP - 1701
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -