Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs

Raoul Orvieto; Jenny Kruchkovich; Jacob Rabinson; Efraim Zohav; Eyal Y. Anteby; Simion Meltcer

doi:10.1016/j.fertnstert.2007.06.022

Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs

Raoul Orvieto
, Jenny Kruchkovich
, Jacob Rabinson
, Efraim Zohav
, Eyal Y. Anteby
, Simion Meltcer

Barzilai University Medical Center

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in poor responders, we compared the stimulation characteristics of 21 cycles, which included the ultrashort gonadotropin-releasing hormone (GnRH) agonist combined with the flexible multidose GnRH antagonist, to the patients' previous failed in vitro fertilization attempts. The use of an ultrashort GnRH-agonist/GnRH-antagonist COH protocol resulted in a statistically significantly greater number of follicles larger than 14 mm on the day of hCG administration, a higher number of oocytes retrieved and embryos transferred, and a reasonable clinical pregnancy rate (14.3%).

Original language	English
Pages (from-to)	228-230
Number of pages	3
Journal	Fertility and Sterility
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2007.06.022
State	Published - 1 Jul 2008

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2007.06.022

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Orvieto, R., Kruchkovich, J., Rabinson, J., Zohav, E., Anteby, E. Y., & Meltcer, S. (2008). Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs. Fertility and Sterility, 90(1), 228-230. https://doi.org/10.1016/j.fertnstert.2007.06.022

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title = "Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs",

abstract = "To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in poor responders, we compared the stimulation characteristics of 21 cycles, which included the ultrashort gonadotropin-releasing hormone (GnRH) agonist combined with the flexible multidose GnRH antagonist, to the patients' previous failed in vitro fertilization attempts. The use of an ultrashort GnRH-agonist/GnRH-antagonist COH protocol resulted in a statistically significantly greater number of follicles larger than 14 mm on the day of hCG administration, a higher number of oocytes retrieved and embryos transferred, and a reasonable clinical pregnancy rate (14.3\%).",

author = "Raoul Orvieto and Jenny Kruchkovich and Jacob Rabinson and Efraim Zohav and Anteby, \{Eyal Y.\} and Simion Meltcer",

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doi = "10.1016/j.fertnstert.2007.06.022",

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Orvieto, R, Kruchkovich, J, Rabinson, J, Zohav, E , Anteby, EY & Meltcer, S 2008, 'Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs', Fertility and Sterility, vol. 90, no. 1, pp. 228-230. https://doi.org/10.1016/j.fertnstert.2007.06.022

Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs. / Orvieto, Raoul; Kruchkovich, Jenny; Rabinson, Jacob et al.
In: Fertility and Sterility, Vol. 90, No. 1, 01.07.2008, p. 228-230.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs

AU - Orvieto, Raoul

AU - Kruchkovich, Jenny

AU - Rabinson, Jacob

AU - Zohav, Efraim

AU - Anteby, Eyal Y.

AU - Meltcer, Simion

PY - 2008/7/1

Y1 - 2008/7/1

N2 - To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in poor responders, we compared the stimulation characteristics of 21 cycles, which included the ultrashort gonadotropin-releasing hormone (GnRH) agonist combined with the flexible multidose GnRH antagonist, to the patients' previous failed in vitro fertilization attempts. The use of an ultrashort GnRH-agonist/GnRH-antagonist COH protocol resulted in a statistically significantly greater number of follicles larger than 14 mm on the day of hCG administration, a higher number of oocytes retrieved and embryos transferred, and a reasonable clinical pregnancy rate (14.3%).

AB - To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in poor responders, we compared the stimulation characteristics of 21 cycles, which included the ultrashort gonadotropin-releasing hormone (GnRH) agonist combined with the flexible multidose GnRH antagonist, to the patients' previous failed in vitro fertilization attempts. The use of an ultrashort GnRH-agonist/GnRH-antagonist COH protocol resulted in a statistically significantly greater number of follicles larger than 14 mm on the day of hCG administration, a higher number of oocytes retrieved and embryos transferred, and a reasonable clinical pregnancy rate (14.3%).

UR - https://www.scopus.com/pages/publications/45849093342

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DO - 10.1016/j.fertnstert.2007.06.022

M3 - Article

C2 - 17681292

AN - SCOPUS:45849093342

SN - 0015-0282

VL - 90

SP - 228

EP - 230

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Ultrashort gonadotropin-releasing hormone agonist combined with flexible multidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs

Abstract

ASJC Scopus subject areas

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