Ultrasonically controlled polymeric drug delivery

J. Kost, K. Leong, R. Langer

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The area of polymeric controlled drug delivery systems has been a field of increasing interest. However, relatively little attention has been given to developing systems in which the rate of delivery can be manipulated externally. We now report that release rates of biologically active substances from a polymeric matrix can be repeatedly modulated from a position external to the environment of use by ultrasonic energy. The ultrasound affects the degradation rate of bioerodible polymers as well as permeation through non‐erodible polymers. The system has been shown to be responsive in vivo. Skin histopathology of the ultrasound treated area didn't reveal any differences between the treated skin and the untreated controls.

Original languageEnglish
Pages (from-to)275-285
Number of pages11
JournalMakromolekulare Chemie. Macromolecular Symposia
Volume19
Issue number1
DOIs
StatePublished - 1 Jan 1988

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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