Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism

M. Machluf; J. Kost

doi:10.1163/156856294X00716

Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism

M. Machluf, J. Kost

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The effect of therapeutic range ultrasound on skin permeability was studied in vitro. Permeating molecule ionization state, pH, ultrasound duration, reversibility of the enhancement phenomenon, and skin structural alterations were evaluated. It was found that ultrasound affects the permeability of both ionized and unionized molecules. No irreversible structural alterations due to the ultrasound exposure were detected in the stratum corneum. Ultrasound enhancing mechanism was discussed.

Original language	English
Pages (from-to)	147-156
Number of pages	10
Journal	Journal of Biomaterials Science, Polymer Edition
Volume	5
Issue number	1-2
DOIs	https://doi.org/10.1163/156856294X00716
State	Published - 1 Jan 1994

Keywords

Skin permeability enhancers
Transdermal drug delivery
ultrasound

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1163/156856294X00716

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abstract = "The effect of therapeutic range ultrasound on skin permeability was studied in vitro. Permeating molecule ionization state, pH, ultrasound duration, reversibility of the enhancement phenomenon, and skin structural alterations were evaluated. It was found that ultrasound affects the permeability of both ionized and unionized molecules. No irreversible structural alterations due to the ultrasound exposure were detected in the stratum corneum. Ultrasound enhancing mechanism was discussed.",

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AB - The effect of therapeutic range ultrasound on skin permeability was studied in vitro. Permeating molecule ionization state, pH, ultrasound duration, reversibility of the enhancement phenomenon, and skin structural alterations were evaluated. It was found that ultrasound affects the permeability of both ionized and unionized molecules. No irreversible structural alterations due to the ultrasound exposure were detected in the stratum corneum. Ultrasound enhancing mechanism was discussed.

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Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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