Abstract
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and future trends in the field of cutaneous vaccination and gene delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 670-676 |
| Number of pages | 7 |
| Journal | Drug Discovery Today |
| Volume | 9 |
| Issue number | 15 |
| DOIs | |
| State | Published - 1 Aug 2004 |
Keywords
- Cell biology
- Drug Discovery
- Pharmaceutical Science
- cavitation
- drug delivery
- permeability
- transdermal delivery
- ultrasound
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
