Ultrasound and transdermal drug delivery

Ilana Lavon, Joseph Kost

Research output: Contribution to journalReview articlepeer-review

164 Scopus citations

Abstract

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and future trends in the field of cutaneous vaccination and gene delivery.

Original languageEnglish
Pages (from-to)670-676
Number of pages7
JournalDrug Discovery Today
Volume9
Issue number15
DOIs
StatePublished - 1 Aug 2004

Keywords

  • Cell biology
  • Drug Discovery
  • Pharmaceutical Science
  • cavitation
  • drug delivery
  • permeability
  • transdermal delivery
  • ultrasound

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