Ultrasound as a potential trigger to terminate the activity of contraceptive delivery implants

J. Kost, L. S. Liu, H. Gabelnick, R. Langer

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In vitro and in vivo experimental results suggest the feasibility of ultrasound as a possible approach to externally affect the release rates and therefore the depletion time of implantable contraceptive delivery systems. For example poly(lactide-coglycolide) microspheres loaded with norethisterone exposed for 2 h to ultrasound at 3 W/cm2 (1 MHz, 20% duty cycle) for 6 consecutive days resulted in depletion times four-fold shorter than microspheres which were not exposed to ultrasound. Scanning electron micrographs of microspheres exposed and not exposed to ultrasound revealed significant effects of ultrasound on the surface morphology of the degrading polymer.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalJournal of Controlled Release
Volume30
Issue number1
DOIs
StatePublished - 1 Jan 1994

Keywords

  • Bioerodible polymer
  • Contraceptive delivery implant
  • Externally regulated drug delivery
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science

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