Ultrasound targeting of Q-starch/miR-197 complexes for topical treatment of psoriasis

Rinat Lifshiz Zimon, Galya Lerman, Einat Elharrar, Tal Meningher, Aviv Barzilai, Moamen Masalha, Ramesh Chintakunta, Etili Hollander, Riki Goldbart, Tamar Traitel, Moti Harats, Yechezkel Sidi, Dror Avni, Joseph Kost

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Psoriasis is a common, worldwide autoinflammatory, incurable skin disease. miR-197 has therapeutic potential for psoriasis since it can down-regulate the expression of both IL-22RA1 and IL-17RA, subunits of the receptors of IL-22 and IL-17, respectively, which are key cytokines in the disease. Although miR-197 has the potential to treat the disease, several inherent physical barrier properties of the skin challenge miRNA's delivery to the target skin cells. In the present study, we evaluated a therapeutic approach that combines the use of ultrasound (US) as a means to enhance skin permeability with quaternized starch (Q-starch) as an miRNA delivery carrier. This resulted in decreased expression of the miR-197 target proteins and in a significant reduction in the psoriatic activity markers. Our results demonstrate the potential of combinations of US and Q-starch/miR-197 complexes for the topical skin treatment of psoriasis.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalJournal of Controlled Release
Volume284
DOIs
StatePublished - 28 Aug 2018

Keywords

  • Psoriasis
  • Starch
  • Topical gene delivery
  • Transdermal
  • Ultrasound
  • miR-197

ASJC Scopus subject areas

  • Pharmaceutical Science

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