TY - JOUR
T1 - Uncovering the geroprotective potential of medicinal plants from the Judea region of Israel
AU - Budovsky, Arie
AU - Shteinberg, Albert
AU - Maor, Hani
AU - Duman, Olga
AU - Yanai, Hagai
AU - Wolfson, Marina
AU - Fraifeld, Vadim E.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Plants growing in the Judea region are widely used in traditional medicine. This phytogeographic zone stands out in its climatic conditions and biodiversity. Consequently, both endemic and widely distributed Mediterranean plants growing in the area have unique chemotypes characterized by accumulation of relatively high levels of phytosteroids. Our comprehensive analysis revealed that many of the plants growing in the Judea region may hold a geroprotective potential. With this in mind, we undertook a wide screen of dozens of candidate herbal extracts for their cell protective, wound-healing, anti-inflammatory, and anti-cancer activities. The results obtained thus far have clearly shown that the extracts tested (1) protect normal human fibroblasts from genotoxic stress (prevent DNA double-strand beaks, increase cell survival and reduce the number of cells undergoing cellular senescence), (2) decrease secretion of pro-inflammatory cytokines, (3) promote wound healing, and (4) exert more pronounced cytotoxicity toward cancer cells.
AB - Plants growing in the Judea region are widely used in traditional medicine. This phytogeographic zone stands out in its climatic conditions and biodiversity. Consequently, both endemic and widely distributed Mediterranean plants growing in the area have unique chemotypes characterized by accumulation of relatively high levels of phytosteroids. Our comprehensive analysis revealed that many of the plants growing in the Judea region may hold a geroprotective potential. With this in mind, we undertook a wide screen of dozens of candidate herbal extracts for their cell protective, wound-healing, anti-inflammatory, and anti-cancer activities. The results obtained thus far have clearly shown that the extracts tested (1) protect normal human fibroblasts from genotoxic stress (prevent DNA double-strand beaks, increase cell survival and reduce the number of cells undergoing cellular senescence), (2) decrease secretion of pro-inflammatory cytokines, (3) promote wound healing, and (4) exert more pronounced cytotoxicity toward cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=84899000793&partnerID=8YFLogxK
U2 - 10.1089/rej.2013.1509
DO - 10.1089/rej.2013.1509
M3 - Article
C2 - 24094064
AN - SCOPUS:84899000793
SN - 1549-1684
VL - 17
SP - 134
EP - 139
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 2
ER -