TY - CHAP
T1 - Understanding Archaeal Protein Translocation
T2 - Haloferax volcanii as a Model System
AU - Eichler, Jerry
AU - Konrad, Zvia
AU - Ring, Gabriela
PY - 2004
Y1 - 2004
N2 - The biogenesis of extra-cytoplasmic proteins requires negotiation of the hydrophobic barrier presented by lipid-based membranes. Unlike the well-defined eukaryal and bacterial protein translocation systems, little is known about how proteins cross into and/or across the plasma membrane of Archaea. In Eukarya and Bacteria, protein translocation occurs at membrane sites composed of evolutionarily conserved core proteins acting together with other domain-specific components. Analysis of archaeal genomes and individual genes from other archaeal strains for which no complete genome sequences are available reveals the existence of archaeal homologues of certain elements of the bacterial or eukaryotic systems, as well as the apparent absence of other components of these two systems (Eichler 2000). Thus, while archaeal translocation represents a hybrid of the bacterial and eukaryotic models, closer examination also reveals the existence of archaeal-specific properties. These could be related to the unique chemical composition of the archaeal membrane or to the extreme conditions in which Archaea can exist, including highly saline environments.
AB - The biogenesis of extra-cytoplasmic proteins requires negotiation of the hydrophobic barrier presented by lipid-based membranes. Unlike the well-defined eukaryal and bacterial protein translocation systems, little is known about how proteins cross into and/or across the plasma membrane of Archaea. In Eukarya and Bacteria, protein translocation occurs at membrane sites composed of evolutionarily conserved core proteins acting together with other domain-specific components. Analysis of archaeal genomes and individual genes from other archaeal strains for which no complete genome sequences are available reveals the existence of archaeal homologues of certain elements of the bacterial or eukaryotic systems, as well as the apparent absence of other components of these two systems (Eichler 2000). Thus, while archaeal translocation represents a hybrid of the bacterial and eukaryotic models, closer examination also reveals the existence of archaeal-specific properties. These could be related to the unique chemical composition of the archaeal membrane or to the extreme conditions in which Archaea can exist, including highly saline environments.
KW - Protein Translocation
KW - Signal Recognition Particle
KW - Archaeal Genome
KW - Signal Recognition Particle Receptor
KW - Archaeal Homologue
UR - https://www.mendeley.com/catalogue/b49f3f99-8b3d-3b06-897d-18786b1c8ab3/
U2 - 10.1007/978-3-662-07656-9_15
DO - 10.1007/978-3-662-07656-9_15
M3 - Chapter
T3 - Halophilic Microorganisms
SP - 215
EP - 228
BT - Halophilic Microorganisms
PB - Springer Berlin Heidelberg
ER -