Unravelling the Therapeutic Potential of Botanicals Against Chronic Obstructive Pulmonary Disease (COPD): Molecular Insights and Future Perspectives

Sicon Mitra, Uttpal Anand, Mimosa Ghorai, Balachandar Vellingiri, Niraj Kumar Jha, Tapan Behl, Manoj Kumar, Radha, Mahipal S. Shekhawat, Jarosław Proćków, Abhijit Dey

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Background: COPD (chronic obstructive pulmonary disease) is a serious health problem worldwide. Present treatments are insufficient and have severe side effects. There is a critical shortage of possible alternative treatments. Medicinal herbs are the most traditional and widely used therapy for treating a wide range of human illnesses around the world. In several countries, different plants are used to treat COPD. Purpose: In this review, we have discussed several known cellular and molecular components implicated in COPD and how plant-derived chemicals might modulate them. Methods: We have discussed how COVID-19 is associated with COPD mortality and severity along with the phytochemical roles of a few plants in the treatment of COPD. In addition, two tables have been included; the first summarizes different plants used for the treatment of COPD, and the second table consists of different kinds of phytochemicals extracted from plants, which are used to inhibit inflammation in the lungs. Conclusion: Various plants have been found to have medicinal properties against COPD. Many plant extracts and components may be used as novel disease-modifying drugs for lung inflammatory diseases.

Original languageEnglish
Article number824132
JournalFrontiers in Pharmacology
Volume13
DOIs
StatePublished - 11 May 2022

Keywords

  • COPD
  • COVID-19
  • alternative therapy
  • clinical efficacy
  • inflammation
  • lungs
  • medicinal plants
  • plant-based formulation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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