Up-regulated day-time orexin-orexin receptor system in human adipose tissue associates with a positive metabolic phenotype

Nikhil Bhandarkar, Yulia Haim, Assaf Rudich, Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka, Yftach Gepner, Nir Goldstein

Research output: Book/ReportBook

Abstract

Background: Orexin (Ox)(A+B) with their receptors (OxR1 and OxR2) constitute a neuroendocrine system regulating sleep/wakefulness, food intake and spontaneous physical activity. The expression of orexin and its receptors in human and rodent adipose tissue yielded inconsistent conclusions. Study aim: To determined the gene expression of Ox-OxR in human subcutaneous (SC) and visceral (omental, OM) adipose tissue and how it relates to adiposity and metabolic (dys)regulation.
Original languageEnglish
DOIs
StatePublished - 15 Feb 2020

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