Upregulation of MHC class i expression following dengue virus infection: The mechanism at the promoter level

Rami Yossef, Benyamin Rosental, Michael Y. Appel, Oren Hershkovitz, Angel Porgador

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Evaluation of: Othman A, Abd Rahman N, Yusof R. Induction of MHC class I HLA-A2 promoter by dengue virus occurs at the NFκB binding domains of the class I regulatory complex. Virus Res. 163(1), 238-245 (2011). Unlike many other viruses that downregulate MHC class I expression on infected cell membranes, flaviviruses were reported to upregulate the MHC class I expression. Dengue virus was shown to induce HLA class I expression; however, the precise transcriptional mechanism that is used by the virus remains unclear. This article assessed the findings of a recently published report describing the mechanism used by dengue virus to induce HLA-A2 expression and characterizing the transcription factors that are involved. The study showed that p50/p65 and p65/65 NF-κB dimers bind to the class I regulatory complex within the HLA-A2 promoter. This finding and its significance for the design of possible antiviral therapeutic agents are discussed in this article.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalExpert Review of Anti-Infective Therapy
Volume10
Issue number3
DOIs
StatePublished - 1 Mar 2012

Keywords

  • class I regulatory complex
  • dengue virus
  • HLA-A2 gene
  • NF-κB

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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