Uptake and secretion of technetium pertechnetate by the rat parotid gland

Philip C. Fox, Lipa Bodner, Mary R. Bowers, Bruce J. Baum

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

1. 1. The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. 2. 2. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. 3. 3. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always < 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. 4. 4. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. 5. 5. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10-4 M NaI. 6. 6. Cells which had accumulated 99mTcO-4showed increased radionuclide efflux after exposure to 10-5 M carbachol.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume83
Issue number3
DOIs
StatePublished - 1 Jan 1986
Externally publishedYes

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