Uptake and secretion of technetium pertechnetate by the rat parotid gland

Philip C. Fox; Lipa Bodner; Mary R. Bowers; Bruce J. Baum

doi:10.1016/0300-9629(86)90149-0

Uptake and secretion of technetium pertechnetate by the rat parotid gland

Philip C. Fox
, Lipa Bodner
, Mary R. Bowers
, Bruce J. Baum

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

1. 1. The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (^99mTcO^-₄) was examined. 2. 2. After intravenous injection, ^99mTcO^-₄ was rapidly detected in parotid saliva. 3. 3. There was an excellent correlation between saliva and plasma ^99mTcO^-₄ levels. The saliva to plasma ratio was always < 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. 4. 4. Output of ^99mTcO^-₄ by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. 5. 5. In vitro, enzymatically dispersed parotid acinar cells accumulated ^99mTcO^-₄ from the incubation medium in a biphasic manner. This uptake was partially blocked by 10^-4 M NaI. 6. 6. Cells which had accumulated ^99mTcO^-₄showed increased radionuclide efflux after exposure to 10^-5 M carbachol.

Original language	English
Pages (from-to)	579-584
Number of pages	6
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1016/0300-9629(86)90149-0
State	Published - 1 Jan 1986
Externally published	Yes

ASJC Scopus subject areas

Physiology

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title = "Uptake and secretion of technetium pertechnetate by the rat parotid gland",

abstract = "1. 1. The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. 2. 2. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. 3. 3. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always < 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. 4. 4. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. 5. 5. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10-4 M NaI. 6. 6. Cells which had accumulated 99mTcO-4showed increased radionuclide efflux after exposure to 10-5 M carbachol.",

author = "Fox, \{Philip C.\} and Lipa Bodner and Bowers, \{Mary R.\} and Baum, \{Bruce J.\}",

year = "1986",

month = jan,

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doi = "10.1016/0300-9629(86)90149-0",

language = "English",

volume = "83",

pages = "579--584",

journal = "Comparative Biochemistry and Physiology -- Part A: Physiology",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Uptake and secretion of technetium pertechnetate by the rat parotid gland

AU - Fox, Philip C.

AU - Bodner, Lipa

AU - Bowers, Mary R.

AU - Baum, Bruce J.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - 1. 1. The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. 2. 2. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. 3. 3. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always < 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. 4. 4. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. 5. 5. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10-4 M NaI. 6. 6. Cells which had accumulated 99mTcO-4showed increased radionuclide efflux after exposure to 10-5 M carbachol.

AB - 1. 1. The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. 2. 2. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. 3. 3. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always < 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. 4. 4. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. 5. 5. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10-4 M NaI. 6. 6. Cells which had accumulated 99mTcO-4showed increased radionuclide efflux after exposure to 10-5 M carbachol.

UR - https://www.scopus.com/pages/publications/0022591150

U2 - 10.1016/0300-9629(86)90149-0

DO - 10.1016/0300-9629(86)90149-0

M3 - Article

AN - SCOPUS:0022591150

SN - 0300-9629

VL - 83

SP - 579

EP - 584

JO - Comparative Biochemistry and Physiology -- Part A: Physiology

JF - Comparative Biochemistry and Physiology -- Part A: Physiology

IS - 3

ER -

Uptake and secretion of technetium pertechnetate by the rat parotid gland

Abstract

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