Abstract
Urinary excretion of vitamin A was studied in patients with multiple myeloma (MM). Eight of the 12 patients studied excreted retinol in urine; only one of them had elevated serum creatinine (115-150 μmol/L). There was a highly significant correlation between urinary retinol and serum creatinine (P < 0.0004). Urinary retinol correlated also with urine protein (P < 0.0001) and albumin (P = 0.001), but not with urinary immunoglobulin light chains. Urinary retinol excretion may be an early manifestation of renal dysfunction in MM patients. The effect of urinary retinol excretion on vitamin A homeostasis in MM deserves further study.
| Original language | English |
|---|---|
| Pages (from-to) | 202-204 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Nov 2003 |
Keywords
- Multiple myeloma
- Proximal tubule dysfunction
- Urinary retinol
ASJC Scopus subject areas
- Hematology